Product Information

MabXpure is the first DAISEP technology-based depletion media developed by DAICEL, and dedicated to mAb industry. This new depletion media features a high selectivity for product and process related contaminant such as host-cell proteins (HCPs), DNA and other impurities, while maintaining high mAb recovery.

MabXpure combines an innovative modified silica with multimodal size exclusion anion exchange chemistries for improved scavenging properties in flowthrough mode under a wide range of conditions including pH, conductivity, buffers, mix ratio, and contact time.

MabXpure can be mixed directly with your cell culture sample and filtered off during harvest or clarification steps (midstream operations), or in dynamic conditions using ready to use formats for polishing step in the purification platform (downstream operations).

MabXpure’s single-use design will streamline process development or ease sample preparation steps. MabXpure protects the platform performance when challenged by non-ideal cell culture contaminant profiles.

SPECIFICATION

Base Matrix Modified Silica
Type Multimodal SEC-AEX
Particle Size (D50V) 35 µm
Recommended Contact Time 1-120 min
Storage Solution / Temperature 20% Ethanol / 4-30°C
pH Stability, CIP (short term) 1-13
pH Stability, working range 2-12

MABXPURE FT

MabXpure FT was developed as pre-filled 1 mL and 5 mL ready to use format for tests in dynamic conditions. MabXpure FT is compatible with common chromatography equipment, low pressure pumps and syringes. MabXpure FT formats can be tested at different loading conditions including pH, conductivity, buffer, residence time.

MABXPURE FT SPECIFICATION

MabXpure FT 1 mL MabXpure FT 5 mL
Bed Dimension 7 mm ID x 25 mm H 16 mm ID x 25 mm H
Recommended Flow Rate 0.2-1 mL/min 1-5 mL/min
Max. Operating Pressure 0.5MPa (72psi) 0.5MPa (72psi)
Column Construction Polypropylene Polypropylene
Inlet Port 10-32 (1/16”) Female 10-32 (1/16”) Female
Outlet Port 10-32 (1/16”) Male 10-32 (1/16”) Male
Storage/Temperature 20% Ethanol / 4-30°C 20% Ethanol / 4-30°C

MABXPURE FT ORDERING INFORMATION

Product Quantities Order Code
MabXpure FT 1 mL 5*1 mL DMXFT0001
MabXpure FT 5 mL 5*5 mL DMXFT0005

For larger volumes, please contact us at cte@daicelbioseparations.com


MABXPURE FT DATA SHEET

DAISEP SPIN

DAISEP Spin columns are designed for small scale mAb purifications, allowing you to mix your filtered or unclarified cell culture sample with depletion media. DAISEP Spin XS and DAISEP Spin XL columns incorporate a SelfSealTM membrane technology which retain the depletion media and sample in the batch incubation chamber. This enables testing various depletion media:sample mix ratios, and contact times. When column is spun at 750 x g in a benchtop centrifuge, the pores of the membrane dilate and the filtered sample is collected in the bottom of the centrifuge tube.

DAISEP SPIN SPECIFICATION

DAISEP Spin XS DAISEP Spin XL
Spin Column Construction Polypropylene Polypropylene, TPE
Mean sinter pore size 0.1-0.2 µm 0.1-0.2 µm
Sinter Construction UHDPE UHDPE
Max G Force 2,500 1,500
Reservoir Capacity (max) 0.6 mL 22 mL

DAISEP SPIN ORDERING INFORMATION

Product Quantities Order Code
DAISEP Spin XS 40 units DSPXS0040
DAISEP Spin XL 8 units DSPXL0008

For larger quantities, please contact us at cte@daicelbioseparations.com


DAISEP SPIN DATA SHEET

MABXPURE

MabXpure bulk depletion media is available in 50 mL and 500 mL. MabXpure is supplied in 20% Ethanol.

MABXPURE SPECIFICATION

MabXpure 50 mL MabXpure 500 mL
Base Matrix Modified Silica Modified Silica
Type Multimodal SEC-AEX Multimodal SEC-AEX
Particle Size (D50v) 35 µm 35 µm
Storage / Temperature 20% Ethanol / 4-30°C 20% Ethanol / 4-30°C
Slurry 50/50 v/v 50/50 v/v
Shelf-life (estimated) 2 years 2 years

MABXPURE ORDERING INFORMATION

Product Quantities Order Code
MabXpure 50 mL 50 mL DMXBK0050
MabXpure 500 mL 500 mL DMXBK0500

For larger quantities, please contact us at cte@daicelbioseparations.com


MABXPURE DATA SHEET

MABXPURE KIT

The MabXpure Kit provides all 3 formats to evaluate the performance of MabXpure under flowthrough and batch conditions.

MABXPURE KIT SPECIFICATION

Product Units
MabXpure MabXpure 50 mL 1 Unit
MabXpure FT MabXpure FT 1 mL 4 Units
MabXpure FT MabXpure FT 5 mL 1 Unit
DAISEP Spin DAISEP Spin XS 2 Units
DAISEP Spin DAISEP Spin XL 3 Units

MABXPURE KIT ORDERING INFORMATION

Product Quantities Order Code
MabXpure Kit 1 Unit DMXKT0001

MABXPURE KIT DATA SHEET
 

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To place an order, please contact us via email using the following address: cte@daicelbioseparations.com

For more information, you can also contact your local support via telephone Tel: +33 (0) 3.88.79.52.00